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KMID : 0352519840210030098
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Korea Univercity Medical Journal
1984 Volume.21 No. 3 p.98 ~ p.106
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The effect of immunosuppresive agent, cyclophosphoamide, and anticoagulants to Hantaan virus
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Abstract
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In 1976, Lee and Lee discovered the etiologic agent of Korean hemorrhagic fever (KHF), Hantaan virus, although similar diseases to KHF had been reported as hemorrhagic nephres:)-nephritis in Russia, as nephropathia epidemica in Scandinavia and epidemic hemorrhagic fever in China.
In 1981, French et al. reported a successful growth of Hantaan virus in A549 cells which originated from alveolar epithelial cells of a human lung cancer.
The growth of Hantaan virus and the appearence of antigen-antibody complex in lung tissues of Apodemus agrarius following intramuscular inoculation of the virus and cyclophosphoamide and also the effect of anticoagulants to infectivity of Hantaan virus in Apodemus agrarius were studied.
The following results were obtained.
1. After inoculation of Hantaan virus in Apodemus agrarius, the formation of immune complex was effectively suppressed by consecutive injection of procytox intramusculary per 36 mg three times at certain intervals.
2. The effect of anticoagulants, EDTA, Heparin and Sod. citrate to infectivity of Hantaan virus in Apodemus agrarius was not demonstrated. Among these, EDTA was the most safe anticoagulant in Hantaan virus experiment.
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